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hasF hasF hasE hasE hasD hasD aprE aprE macB macB macB2 macB2 aprD aprD aprA aprA PSEEN2195 PSEEN2195 PSEEN3929 PSEEN3929 PSEEN0145 PSEEN0145
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hasFHeme acquisition outer membrane efflux protein HasF; Function of homologous gene experimentally demonstrated in an other organism; transporter. (444 aa)    
Predicted Functional Partners:
hasE
Heme acquisition transporter, membrane fusion protein HasE; Function of homologous gene experimentally demonstrated in an other organism; transporter.
 
 
 0.934
hasD
Heme acquisition ABC transporter HasD, ATP binding protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.895
aprE
Alkaline protease (aprA) secretion protein aprE; Function of homologous gene experimentally demonstrated in an other organism; transporter.
 
 
 0.738
macB
Macrolide ABC efflux protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.594
macB2
Putative efflux ABC transporter, ATP-binding/permease protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.594
aprD
Alkaline protease (aprA) secretion protein aprD; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.580
aprA
Alkaline metalloprotease precursor AprA; Secreted protease which is important for P.entomophila to counteract the local immune response of Drosophila. Can degrade antimicrobial peptides (AMPs), e.g. Diptericin and Cecropin A. Thus, protects P.entomophila from the Drosophila antimicrobial peptides produced by the gut innate immune response, and promotes bacterial persistence in the Drosophila gut and killing of the host. Is responsible for maturation of pro-Monalysin to the active toxin Monalysin, by cleaving its N-terminus ; Belongs to the peptidase M10B family.
 
  
 0.553
PSEEN2195
Triacylglycerol lipase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.534
PSEEN3929
Type I secretion membrane fusion protein, HlyD; Function of strongly homologous gene; transporter.
 
 
 0.518
PSEEN0145
Putative type I toxin efflux membrane fusion protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter.
 
 
 0.514
Your Current Organism:
Pseudomonas entomophila
NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48
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